The primary purpose of this book is to present quantitative forecasting of the mid-term probability of large earthquakes both globally and over various regions of the world.  The author used the novel seismic activity regression formula to calculate the probability of an earthquake, in the global and major seismic zones, with any given magnitude at any given time since the most recent earthquake of the same magnitude. This book is the author's 50+ years accumulation of achievements in researching and teaching geophysics and seismology for mitigation of earthquake disasters. The author hopes that those after him will find the methodology in this book to be helpful in limiting the death and destruction caused by earthquakes of catastrophic magnitude.